Scientists have identified a novel group of epicardial stem cells that can differentiate into cardiomyocytes.

William Pu (Harvard Medical School, Boston, Massachusetts, USA) and colleagues report in the journal Nature that a subset of epicardial cardiogenic precursors expressing the transcription factor Wt1, and originating in the epicardium, differentiate into fully functional cardiomyocytes in mice.

The team made the surprise discovery while studying another transcription factor, GATA4, in epicardial cells.

"The tool we created for that experiment irreversibly marks the cells involved, so you can ...

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