Patients with Marfan's syndrome can benefit from treatment with angiotensin receptor II blockers (ARBs), study results indicate.

The main cause of premature death in patients with Marfan's syndrome is progressive enlargement of the aortic root leading to dissection.

Recent studies suggest that aortic-root enlargement is caused by excessive signaling by transforming growth factor (TGF)-β, which could be reduced by treatment with TGF-β antagonists, including angiotensin II-receptor blockers (ARBs), say the researchers.

Harry Dietz (Johns Hopkins University School of Medicine, Baltimore, Maryland, USA) and ...

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