Abstract

Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare malignancy of the female genital tract with a poorer clinical outcome than squamous cell carcinoma of the uterine cervix.

We report a case of pure basaloid squamous cell carcinoma of the uterine cervix. A 70-yr-old woman with vaginal bleeding was referred to our institute.

A basaloid squamous cell carcinoma of the uterine cervix, of International Federation of Gynecology and Obstetrics (FIGO) stage Ib1, was diagnosed by a loop electrosurgical excision procedure cone biopsy.

A radical hysterectomy was performed, along with bilateral salpingo-oophorectomy, pelvic lymph node dissection, and para-aortic lymph node sampling.

Pathologic findings were consistent with a basaloid squamous cell carcinoma confined to the cervix without an extracervical tumor. No further treatment was administered and there was no clinical evidence of recurrence during the 12 months of follow-up. Follow-up for the patient is ongoing.

Although basaloid squamous cell carcinoma of the uterine cervix is thought to behave aggressively, accumulation of data on these rare tumors is necessary to determine whether their behavior differs significantly from that of conventional cervical squamous cell carcinoma of similar clinical stage.

These data would be useful for defining the best diagnosis and treatment for these rare tumors.

Keywords: Basaloid, Carcinoma, Squamous Cell, Cervix Uterine

INTRODUCTION

Basaloid squamous carcinoma of the uterine cervix is a rare tumor type characterized by an ulcerated, infiltrating growth pattern; nests or cords of small basaloid cells; prominent peripheral palisading of cells in the tumor cell nests; and the absence of significant stromal reaction (1). These tumors can arise from various anatomic sites, including the hypopharynx, base of the tongue, salivary glands, esophagus, anal canal, prostate, thymus, vulva, and urinary bladder (2-12), but origin of uterine cervix is rare. Basaloid squamous carcinoma of the uterine cervix is neither recognized nor included as a specific histologic subtype in the current World Health Organization (WHO) classification of cervical tumors. Since basaloid squamous carcinomas are thought to behave aggressively (13) but the evidence of supprting this behavior is not powerful, accurate diagnosis and accumulated data of this tumor are important for their clinical management and prognosis.

doi: 10.3346/jkms.2009.24.3.542.

Yong Soon Kwon,^1* Yong Man Kim,¹ Ga Won Choi,² Young Tak Kim,¹ and Joo-Hyun Nam¹

1Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. 2Department of Pathology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.

Corresponding author. Address for correspondence: Yong-Man Kim, M.D. Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, 388-1 Pungnap-2-dong, Songpa-gu, Seoul 138-736, Korea. Tel: +82.2-3010-3640, Fax: +82.2-3010-6944, Email: ymkim@amc.seoul.kr

^*Current address: Department of Obstetrics and Gynecology, College of Medicine, Kwandong University, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea.

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